Category: latest-publications
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Beyond exhaustion: the unique characteristics of CD8+ T cell dysfunction in chronic HBV infection
Thimme, R., Bertoletti, A. & Iannacone, M. Beyond exhaustion: the unique characteristics of CD8+ T cell dysfunction in chronic HBV infection. Nat Rev Immunol (2024). https://doi.org/10.1038/s41577-024-01097-3
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A rapid method to assess the in vivo multi-functionality of adoptively transferred engineered TCR T cells
The clinical efficacy of chimeric antigen and T cell receptor (TCR) T cell immunotherapies is attributed to their ability to proliferate and persist in vivo. Since the interaction of the engineered T cells with the targeted tumour or its environment might suppress their function, their functionality should be characterized not only before but also after…
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Fratricide-resistant CD7-CAR T cells in T-ALL
Oh, B.L.Z., Shimasaki, N., Coustan-Smith, E. et al. Fratricide-resistant CD7-CAR T cells in T-ALL. Nat Med (2024). https://doi.org/10.1038/s41591-024-03228-8
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T cell hybrid immunity against SARS-CoV-2 in children: a longitudinal study
Qui M, Hariharaputran S, Hang SK, Zhang J, Tan CW, Chong CY, Low J, Wang L, Bertoletti A, Yung CF, Le Bert N. T cell hybrid immunity against SARS-CoV-2 in children: a longitudinal study. EBioMedicine. 2024 Jul;105:105203. doi: 10.1016/j.ebiom.2024.105203. Epub 2024 Jun 18. PMID: 38896919; PMCID: PMC11237860.
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Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children.
Zhong Y, Kang AYH, Tay CJX, Li HE, Elyana N, Tan CW, Yap WC, Lim JME, Le Bert N, Chan KR, Ong EZ, Low JG, Shek LP, Tham EH, Ooi EE. Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children. Nat Med. 2024 Apr 30. doi: 10.1038/s41591-024-02962-3.
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Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination.
Chong CY, Kam KQ, Zhang J, Bertoletti A, Hariharaputran S, Sultana R, Piragasam R, Mah YY, Tan CW, Wang L, Yung CF. Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination. Vaccine. 2024 Apr 30;42(12):2951-2954. doi: 10.1016/j.vaccine.2024.04.011.
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SARS-CoV-2 immunity.
Bertoletti A. SARS-CoV-2 immunity. Cell Mol Immunol. 2024 Feb;21(2):101-102. doi: 10.1038/s41423-024-01128-y.
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Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy.
Chen Q, Chia A, Hang SK, Lim A, Koh WK, Peng Y, Gao F, Chen J, Ho Z, Wai LE, Kunasegaran K, Tan AT, Le Bert N, Loh CY, Goh YS, Renia L, Dong T, Vathsala A, Bertoletti A. Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy. Cell Mol Immunol. 2023 Nov;20(11):1300-1312.…
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BNT162b2 vaccine induced variant-specific immunity, safety and risk of Omicron breakthrough infection in children aged 5 to 11 years: a cohort study.
Yung CF, Le Bert N, Kam KQ, Saffari SE, Tan CW, Mah YY, Zhang J, Yeoh AY, Zhu F, Hariharaputran S, Chong CY, Bertoletti A, Wang L. BNT162b2 vaccine induced variant-specific immunity, safety and risk of Omicron breakthrough infection in children aged 5 to 11 years: a cohort study. Sci Rep. 2023 Oct 13;13(1):17337. doi:…
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Lytic efficiency of immunosuppressive drug-resistant armoured T cells against circulating HBV-related HCC in whole blood.
Lin M, Bhakdi SC, Tan D, Lee JJX, Tai DWM, Pavesi A, Wai LE, Wang T, Bertoletti A, Tan AT. Lytic efficiency of immunosuppressive drug-resistant armoured T cells against circulating HBV-related HCC in whole blood. Immunother Adv. 2023 Aug 14;3(1):ltad015. doi: 10.1093/immadv/ltad015.