Category: selected-publications
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Effects of Hepatitis B Surface Antigen on Virus-Specific and Global T Cells in Patients With Chronic Hepatitis B Virus infection.
Le Bert N, Gill US, Hong M, Kunasegaran K, Tan DZM, Ahmad R, Cheng Y, Dutertre CA, Heinecke A, Rivino L, Tan A, Hansi NK, Zhang M, Xi S, Chong Y, Pflanz S, Newell EW, Kennedy PTF, Bertoletti A. Gastroenterology. 2020;159:652-664. Background & aims: Chronic hepatitis B virus (HBV) infection is characterized by the presence…
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Prevalence and Functional Profile of SARS-CoV-2 T Cells in Asymptomatic Kenyan Adults.
Background. SARS-CoV-2 infection in Africa has been characterized by a less severe disease profile than what has been observed elsewhere, but the profile of SARS-CoV-2–specific adaptive immunity in these mainly asymptomatic patients has not, to our knowledge, been analyzed. Methods. We collected blood samples from residents of rural Kenya (n = 80), who had not…
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SARS-CoV-2 Breakthrough Infection in Vaccinated Individuals Induces Virus-specific Nasal-resident CD8 and CD4 T Cells of Broad Specificity.
Lim J, Tan AT, Le Bert N, Hang SK, Low J, Bertoletti A. J Exp Med. 2022, 219, e20220780. Rapid recognition of SARS-CoV-2–infected cells by resident T cells in the upper airway might provide an important layer of protection against COVID-19. Whether parenteral SARS-CoV-2 vaccination or infection induces nasal-resident T cells specific for distinct SARS-CoV-2…
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Rapid Measurement of SARS-CoV-2 Spike T Cells in Whole Blood from Vaccinated and Naturally Infected Individuals.
Tan AT, Lim JME, Le Bert N, Kunasegaran K, Chia A, Qui M, Tan N, Chia WN, de Alwis R, Ying D, Sim JXY, Ooi EE, Wang LF, Chen MC, Young BE, Hsu LY, Low JGH, Lye DC, Bertoletti A. J.Clin. Invest. 2021 131(17). Defining the correlates of protection necessary to manage the COVID-19 pandemic…
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Pre-existing Polymerase-specific T Cells Expand in Abortive Seronegative SARS-CoV-2.
Swadling L, Diniz MO, Schmidt NM, Amin OE, Chandran A, Shaw E, Pade C, Gibbons JM, Le Bert N, Tan AT, Jeffery-Smith A, Tan C, Tham CYL, Kucykowicz S, Aidoo-Micah G, Rosenheim J, Davies J, Johnson M, Jensen MP, Joy G, McCoy LE, Valdes AM, Chain BM, Goldblatt D, Altmann DM, Boyton RJ, Manisty C,…
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SARS-CoV-2-specific T Cell Immunity in Cases of COVID-19 and SARS, and Uninfected Controls.
Le Bert N, Tan AT, Kunasegaran K, Tham CYL, Hafezi M, Chia A, Chng MHY, Lin M, Tan N, Linster M, Chia WN, Chen MI, Wang LF, Ooi EE, Kalimuddin S, Tambyah PA, Low JG, Tan YJ, Bertoletti A. Nature. 2020, 584:457-462. Memory T cells induced by previous pathogens can shape susceptibility to, and the…
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Immunosuppressive Drug Resistant Armored TCR T cells for Immune-therapy of HCC in Liver Transplant Patients.
Hafezi M, Lin M, Chia A, Chua A, Ho ZZ, Fam R, Tan D, Aw J, Pavesi A, Krishnamoorthy TL, Chow WC, Chen W, Zhang Q, Wai LE, Koh S, Tan AT, Bertoletti A. Hepatology. 2020 Nov 29. Background & aims: HBV-specific T-cell receptor (HBV-TCR) engineered T cells have the potential for treating HCC relapses…
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Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.
Tan AT, Yang N, Lee Krishnamoorthy T, Oei V, Chua A, Zhao X, Tan HS, Chia A, Le Bert N, Low D, Tan HK, Kumar R, Irani FG, Ho ZZ, Zhang Q, Guccione E, Wai LE, Koh S, Hwang W, Chow WC, Bertoletti A. Gastroenterology. 2019 May;156(6):1862-187. Background and aims: Hepatocellular carcinoma (HCC) is often…